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this is a fairly benign issue. just change project com interop settings to *not* attempt to unregister the object during compilation, and it should work. otherwise, you may also have to stop/restart services to get a stuck process, or dll unloaded.

error message(s) :
COM Interop unregistration failed. unable to load file.
COM Interop registration failed. could not load the assembly to be registered.

knowledgebase article:
http://msdn.microsoft.com/library/default.asp?url=/library/en-us/vbref/html/vberrUnregistrationForCOMInteropFailed.asp